Hughes ‘lines up £4m bid for Wolves keeper’

first_imgMark Hughes has pencilled in a £4m bid to take Wolves goalkeeper Wayne Hennessey to QPR, the Daily Star say.Manager Hughes is said to be planning to table an offer for the 25-year-old if Rangers stay up and Wolves are relegated.Hughes knows the Wales international well and is tipped to make a move for him as soon as the season ends.Meanwhile, Manchester City are reported to be planning to re-sign Daniel Sturridge from Chelsea in the summer.There has been speculation about Sturridge’s future for some time and the Manchester Evening News say City, who sold him to Chelsea three years ago, want to take him back to Eastlands.David Luiz has reportedly been ruled out of Wednesday’s Champions League semi-final clash with Barcelona and is likely to miss the second leg too.The Chelsea defender was declared doubtful for this week’s game after being carried off with a hamstring injury during the FA Cup victory over Tottenham at Wembley on Sunday.The Sun say Luiz will definitely miss Barca’s visit to Stamford Bridge as well as this weekend’s vital league game against Arsenal – and is unlikely to be fit in time for the Blues’ trip to the Nou Camp.And ex-Chelsea striker Nicolas Anelka has reiterated his desire to see Blues star Didier Drogba join him at Chinese club Shanghai Shenhua along with former Paris St-Germain man Selim Benachour.The Sun quote Anelka as saying: “I hope Benachour and Drogba will quickly join us.”Follow West London Sport on TwitterFind us on Facebooklast_img read more

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How Long Can DNA Survive?

first_imgAn international team of scientists takes issue with recent claims that ancient DNA has been found in ice, amber, salt or rock many millions of years old (see 05/23/2002 entry, for instance).  They think such cases are due to contamination and have not been independently replicated.  They gathered samples in Siberian and Antarctic permafrost under ideal conditions for preservation, and found that DNA would become unrecognizable after millions of years due to increasing numbers of interstrand crosslinks.  Their report, published in the Jan. 6 issue of Current Biology,1 puts an upper limit at 400,000 years on the durability of DNA.    Unexpectedly, they found that non-spore-forming gram-positive Actinobacteria seems to survive the longest.  This was surprising, because endospores were assumed to be the hardiest of all cell types.  An endospore has no DNA-repair activity, so maybe that’s the reason.  They offer some other possibilities:The mechanism behind the superior persistence of DNA from the non-spore-forming-GP Actinobacteria is currently unknown.  Slow but continuous metabolic activity and DNA repair at subzero temperatures is one possibility.  Adaptations connected to dormancy might be another explanation.  Finally, the DNA could simply originate from dead bacteria, whose DNA for some reason, e.g., structural features, survived better.Willerslev et al., “Long-term persistence of bacterial DNA,” Current Biology, Vol 14, R9-R10, 6 January 2004.Do any of those possibilities sound plausible to you?  Actually, DNA probably degrades much faster than they estimate.  There’s no way they could verify the 400,000 year figure; it’s a pure guess, based on certain assumptions.  At most, it is just an upper limit.  If DNA could survive the onslaughts of nature for so long, it would speak of designed mechanisms to fight the degrading pressure of entropy.(Visited 15 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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SA begins single-dose HIV drug roll-out

first_img8 April 2013 About 180 000 HIV-positive South Africans will soon start taking fixed-dose combination antiretroviral (ARV) medication, which involves one tablet instead of three to five pills a day, reducing the risk of patients defaulting from treatment. Health Minister Aaron Motsoaledi launched the single-dose ARVs at Phedisong 4 Community Health Clinic in Ga-Rankuwa outside Pretoria on Monday. The fixed-dose combination (FDC) ARV will be given to newly diagnosed HIV-positive people, HIV-positive pregnant women and breast-feeding mothers. Motsoaledi said the department had revised the guidelines for prevention of mother-to-child transmission, paediatric and adult treatment due to changes in the treatment regime for FDC ARVs. The fixed-dose combination – containing emtricitabine, efavirenz and tenofovir – is a multiple antiretroviral drug combined into a single pill, which helps reduce pill burden. It is easy to take, highly effective and in no way inferior to taking three individual drugs.Pregnant HIV-positive women “We also decided that all pregnant HIV-positive women will be started on the FDC, regardless of their CD4 count. They will stay on treatment until they complete breastfeeding. They will continue on treatment should their CD4 count be 350 or below,” Motsoaledi said. “More than 7 000 doctors and nurses have been updated on the new guidelines and we’ve ensured that at least one [or two] health care professionals in each facility have been updated.” In addition, more than 200 master trainers have been trained, including those based at regional training centres and those stationed at the department’s development partners. Eligible patients will get one month’s supply of FDC pills for the first three months. “They will see their clinicians monthly for three months so that they can be carefully monitored. Thereafter, if they are stable they, will be given three months’ supply of FDCs. “From June onwards, all other stable, non-complicated patients will be switched to FDCs after consultation with their clinicians,” he said. A pregnancy register has been introduced at selected sites to conduct surveillance on adverse drug reactions. Motsoaledi explained that it was standard clinical practice worldwide to monitor drug reactions. “We need to carefully monitor reactions of patients on drugs and take action when we see any systematic adverse events.”‘Treatment without disruption’ Motsoaledi said he was confident that they had sufficient supplies of ARVs for all patients who are eligible for the FDC pills as the department had been working with three suppliers to ensure that they are able to supply them the requisite quantities without disruption. “In order to ensure uninterrupted supply of ARV medicines on the new tender, the national Department of Health has initiated monthly supplier meetings to discuss forecasted demand for the following three months so that manufacturers can plan their manufacturing accordingly,” he said. Data has been collected from provincial depots on a weekly basis and analysed in order to identify weaknesses in the supply chain, which are then addressed either with the province or the supplier depending on the nature of the problem. To date, 389 857 units of FDC pills have been supplied to the provinces. A further 915 000 units are expected to be delivered during the course of April. The volume units are expected to increase to 1.5-million per month by September this year to allow all patients – including switching existing, stable patients currently taking three individual ARV drugs – to have access to the pills. Currently, 1.7-million patients are on ARV treatment, and the department hopes to expand this to 2.5-million by the end of 2014. One of the first beneficiaries of the FDC pills, Andrew Mosane from Ga-Rankuwa Zone 4, is the Gauteng secretary for the Treatment Action Campaign. Mosane said the new drug would make his life easier. “It’s going to be less stress than taking five tablets a day, and everybody will have access to it. [This will] improve peoples’ lives,” he said. Source: SANews.gov.zalast_img read more

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Johannesburg developing entrepreneurs who make a difference

first_img5 May 2016Welcome! #JoziMyBeginning pic.twitter.com/qzazOYJbED— JoziMyBeginning (@JoziMyBeginning) April 19, 2016A City of Johannesburg business initiative, Jozi: My Beginning, announced the final 17 ventures selected from over 2 000 entrants to receive a financial helping hand from the city. It will allow them to grow and compete in the marketplace, while creating jobs and boosting the economy.The initiative forms part of the [email protected] program that is setting aside R50-million to fund local talent with innovative business ideas that can benefit the public and enrich the lives of local [email protected] Mayor @ParksTauCOJ explains the COJ’s excitement to be a part of the #JoziMyBeginning initiative pic.twitter.com/ve9PZLN1sy— JoziMyBeginning (@JoziMyBeginning) April 19, 2016Announcing the results on 20 April 2016, Johannesburg mayor Mpho Parks Tau congratulated the 17 businesses selected to develop its ideas further, adding how vital it was for the businesses to provide local solutions to local problems, saying it should not always be on the shoulders of the municipality.The mayor also noted the need for these businesses to be able to compete successfully nationally and internationally, saying “local solutions to local problems help us grow enterprises into not only locally competitive enterprises but into internationally competitive enterprises”.Two of the finalists have developed unique ideas that show promise for servicing the community. One addresses the challenges of shack fire prevention and the other tries to solve the issue of rubbish collection and recycling.Fireproofing informal settlementsJonathan Frost and Peter Barthel spent years developing a viable solution to the problem of shack fires in and around the city.Through trial and error tests, the pair came up with a safe chemical applicant that can be used to curb the spread of fires in any home.“[The concept is] a fire-proofing material that you can apply onto any structure for example glass [or] metal surfaces for your informal settlements. We want to prevent the spread of fire from the source hence securing the rest of the dwellings surrounding them so that they don’t get damaged,” Frost told news website, News24.According to Frost, the applicant can be applied to the inside of an informal home made up of timber frames and metal parts.“The chemicals will reduce the burn properties of wood and wood products and will give shack dwellers a chance to either douse the fire or vacate the shack in time. It will also prevent spreading of fires to adjacent shacks,” Frost said.The chemical solution is easy to apply and can be done as one would apply plaster on a wall, he said. There would be initial training involved with individuals in the community interested in using the product, and they would then get an opportunity to start their own business in their respective communities, selling the product to the residents.The product is currently undergoing various health and safety tests, but the outcome for the idea looks positive. Considering the product’s selection for Jozi: My Beginning, Frost said “we’re very privileged to have been chosen. I’m looking forward to developing the product fully”.A fresh take on trash collectionSifiso is using media as a catalyst for social change. His project, #abomakgereza recently did a clean-up of Jozi! pic.twitter.com/sZglZR8t3V— Spark* South Africa (@SparkINT_SA) April 1, 2015Abomakgereza, a recycling idea with a difference, has been developed by Soweto entrepreneur Sifiso Ngobese, who looked at improving safety of “recycling riders” – those who sift through rubbish to collect and sell recyclables. “The biggest problem that the [riders] face on a regular basis is that the trolleys they use break down easily and have poor visibility at night,” Ngobese said about the genesis of the idea.Ngobese and his team designed and built a safer, roadworthy and more functional trolley that riders could use to collect, as well generate some extra income. To finance the manufacturing, Ngobese sold advertising space on the trolleys, “it doubles up as a mobile billboard where companies can advertise their brand and add content on the trolley,” he explained, adding that 10% of all business profits for the companies generated from the advertising will be distributed to the trolley riders, in the form of food, financial support and anything else the recyclers may need.The company is beginning to create a database of registered, vetted riders that could be accessed by both potential advertisers as well as the municipality. The system can track the identities and number of riders operating in a specific area, as well as the amount of recycling items the trolleys pick up.The project currently has 40 recycling riders registered on its database. With the help of the Jozi: My Beginning initiative, Ngobese would like to increase that number to 100.Those who will be at the 702 walk the talk looking out for #Abomakgereza with branded trolleys cleaning up the venue. pic.twitter.com/UwzNmQLgK5— Abomakgereza (@ngobese_sifiso) July 24, 2015The idea has also developed into waste management services for special events, such as the 702 Walk The Talk race in 2015 which saw recyclers using their trolleys to tidy up after the event.Ngobese hopes the Abomakgereza business concept, now with backing from the City of Johannesburg, can branch out into full time waste management as a supplementary service with larger waste pick up companies to serve more areas of the community.Sources: News24/News24last_img read more

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Ordinary South Africans Doing Amazing Things – Jozi Cats Rugby Club

first_imgOrdinary South Africans Doing Amazing Things – Jozi Cats Rugby ClubBrand South Africa’s Play Your Part initiative makes emphasis on inspiring all South Africans to contribute to positive change, get involved and become active citizens, in order to contribute to the National Development Plan’s (NDP) vision 2030. The NDP defines active citizenship as equalising opportunities and enhancing human capabilities. It serves as an action plan for securing the future for all citizens as charted in the Constitution.Jozi Cats are one such example of being on the path of contributing to the Play Your Part mandate of inspiring and encouraging active citizenship. As a registered Non-profit Organisation (NPO), Jozi Cats is Africa’s first gay-inclusive, competitive rugby club, that stands for being a people association first, a sporting organisation second and a community change-maker third.Jozi Cats live and breathe its values at all times, on and off the field to inspire local and global sporting bodies such as the Lesbian, Gay, Bisexual, Transgender, Queer or Questioning, and Intersex (LGBTQI*) and GNC (Gender Non-conforming) communities.As Africa’s first gay and inclusive rugby club, Jozi Cats sit at the centre of the conversation on the continent as #ChangeMakers. Of the 55 African states recognised by the United Nations or the African Union, homosexuality is outlawed in 34 African countries.South Africa, the only country on the continent where sexual orientation is protected by the constitution. Jozi Cats exists to provide a safe space for all its diverse communities to enjoy the game of rugby, whether as a player, a referee, or spectator, regardless of sexual orientation, gender identification, age, race or ability.“Founded on 20th August 2015, we began our journey with a simple idea of creating a safe and harassment-free environment for everyone to enjoy the game of rugby, along with building a competitive, social and diverse club which welcomes players with all levels of experience who enjoy a love for rugby”, said Mr Chris Verrijdt; Chairman – Jozi Cats Rugby Club.In February 2016 Jozi Cats reached out to find support to recruit new members and increase the visibility of the club. Havas PR devised a bold campaign that turned gay stereotypes inside out by challenging you to ask “what does a gay rugby player look” and used the typical gay slurs one would here on the sports field to tackle homophobia in rugby.The “Rugby, That’s so Gay” Campaign launched on May 4th, 2016 and went viral. The Jozi Cats campaign was viewed by over 350 million people in over 146 countries worldwide.Over the last three years Jozi Cats has constantly and consistently disrupted the local and global narrative around what it means to be LGBTQI* in the rugby world, with a series of history-making moments under its belt providing inspiration through perspiration to the continent as a whole:First gay and inclusive rugby club in Africa (2015)Global “Rugby That’s So Gay” campaign seen by 315 million people in 126 countries (2016)First inclusive rugby tour across South Africa (2016)First inclusive touch rugby tournament – The Reconciliation Cup in Cape Town (2016)First African team to participate in an international inclusive Rugby Tournament in Madrid – The Union Cup (2017)Historic MOU signing with Digger’s Rugby Club to tackle homophobia in Rugby (2017)Formation of the Khayelitsha Cats – a touch club for lesbian players of colour in Cape Town (2017)First African Rugby Club to attain membership status in International Gay Rugby Organisation (IGR) (2018)First Inclusive Tag Rugby Tournament in Africa with an endorsement from Network of African National Human Rights Institutions, South African Human Rights Commission, Tag Rugby South Africa and SARU (2018)When asked which sports Jozi Cats will break stereotypes next, Mr Verrijdt said; “We are constantly shifting stereotypes and creating an inclusive world of sports, I think soccer might just do.”For more information on these Ordinary South Africans Doing Amazing Things – Jozi Cats Rugby Club, log on to www.jozicats.co.za or like facebook.com/JoziCats and follow @JoziCats on Instagram and Twitter for regular updates.Also, contact: Chris Verrijdt: Chairman – Jozi Cats Rugby ClubCell:   +27 82 784 6 Inclusivity. Diversity. Equality.645 | Email: [email protected]last_img read more

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Does Apple Ever Regret Making The iPad Mini?

first_imgThe Rise and Rise of Mobile Payment Technology Role of Mobile App Analytics In-App Engagement Related Posts Why IoT Apps are Eating Device Interfaces dan lyonscenter_img There are so many reasons to love this photo of Apple marketing boss Phil Schiller holding up an iPad Mini. For one thing, it captures the kind of hushed sanctimony and reverence with which Apple introduces things that are, essentially, little plastic gizmos. But mostly I love Phil’s weird off-camera gaze, which reminds me of this photo from Stepbrothers. What is he looking at? What’s he thinking? Is he fearful, even then, on the day of the introduction, that this cool new device is going to kill sales of the bigger iPads and thus drag down Apple’s profit margins?(See also Is The iPad MIni The “Real” iPad?)If so, then Phil was right, because apparently that’s what’s happening, according to a report from Digitimes, which claims Apple is cutting back orders for components used in the big iPad and now expects to sell fewer of them than originally expected. Mostly because it’s selling so many of these goddamn iPad Minis.Digitimes says Apple originally planned to sell 60 million big iPads and 40 million Minis, but that now Apple expects to sell 33 million big ones and 55 million little guys. That’s great news if you’re the product manager in charge of the iPad Mini – you’re having a blowout year! But you’ll notice that the new sum total of all iPad sales for the year stands at 88 million, which is less than the previously expected 100 million. This is not good. My Entire Premise Could Be False, In Which Case, SorryThen again this entire report could be bullshit, since it comes from Digitimes, and Digitimes is perhaps not the most reliable publication in the world, as reflected in the headline the story to which I linked, which mentions issues with Apple’s “supplpy” (sic) chains.But if the report is true, this means Apple will sell fewer overall iPads (of all kinds) than originally expected. And more of what it does sell will be the less-expensive Mini model.That in turn means Apple is likely to make less profit margin, as the financial wizards at Business Insider point out.Does Phil Schiller sometimes lie awake at night wishing Apple had never made that damn Mini? Does he lurk outside Apple stores and curse the cheap bastards who keep buying Minis just because they’re $170 cheaper than the big one? Maybe not. Maybe Phil and his team figure they pulled off a pretty amazing coup. They milked ridiculous margins out of the original iPad for a long, long time. And now that big iPad serves a purpose – it makes the iPad Mini look cheap. Which it’s not, considering that you can get roughly comparable Android tablets for a lot less. (See also The iPad MIni’s Killer Feature = Price.)Apple stock is up a bit today to $427, so apparently Wall Street is taking the Digitimes report with a grain of salt. Photo by Reuters.  What it Takes to Build a Highly Secure FinTech … Tags:#Apple#iPad#iPad mini last_img read more

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I’m being unfairly singled out, says Navjot Singh Sidhu

first_imgAt the receiving end of Punjab Chief Minister and Congress leader Amarinder Singh’s criticism after the Lok Sabha poll results, State Local Bodies Minister Navjot Singh Sidhu on Thursday said he was being unfairly singled out in the name of poor performance of his department. Mr. Sidhu said the Ministry had worked in the most transparent manner. “The department has been able to generate ₹6,000 crore and all its projects are being completed on a war-footing.” There were a few people who didn’t want him in the party, he said. After the elections, Capt. Singh said he would take up with the Congress high command Mr. Sidhu’s “damaging remarks”, which might have led to the defeat in the Bathinda seat. He also said that Mr. Sidhu’s performance should be reviewed. Reacting to the remarks, Mr. Sidhu said the party had never been able to win the seat in the past 40 years. “Capt. Amarinder and his son Raninder Singh also lost from Bathinda,” he said.last_img read more

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